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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CANX All Species: 41.82
Human Site: T267 Identified Species: 61.33
UniProt: P27824 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27824 NP_001019820.1 592 67568 T267 G N L L N D M T P P V N P S R
Chimpanzee Pan troglodytes XP_001151304 592 67554 T267 G N L L N D M T P P V N P S R
Rhesus Macaque Macaca mulatta XP_001101429 592 67582 T267 G N L L N D M T P P V N P S R
Dog Lupus familis XP_533285 610 69806 V258 G S L L E D V V P P I N P P K
Cat Felis silvestris
Mouse Mus musculus P35564 591 67259 T268 G N L L N D M T P P V N P S R
Rat Rattus norvegicus P35565 591 67236 T268 G N L L N D M T P P V N P S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506871 598 67609 T270 G N L L N D M T P A V N P P R
Chicken Gallus gallus NP_001025791 599 68090 S268 G N L L N D M S P P V N P P R
Frog Xenopus laevis NP_001080326 611 69964 S279 G S L L N D M S P P V N P P S
Zebra Danio Brachydanio rerio NP_998613 600 67856 T275 G S L L N D V T P P V N P P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29413 406 46790 I208 D F L A P K K I K D P T A T K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34652 619 69189 T259 G N M M S D V T P A L T P P K
Sea Urchin Strong. purpuratus XP_791226 591 66512 S262 G S L L S D M S P P V N P P A
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SP22 420 47921 P222 K D P E A K K P E D W D D K E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P29402 530 60468 D250 P N A V K P E D W D E D A P M
Baker's Yeast Sacchar. cerevisiae P27825 502 56949 R264 H D W D D R I R I P D P E A V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.6 59.1 N.A. 93 93.5 N.A. 85.7 82.8 78.2 70.8 N.A. 31.7 N.A. 40.5 53.7
Protein Similarity: 100 99.8 99.4 75.2 N.A. 96.6 97.4 N.A. 93.1 90.8 86.2 84.1 N.A. 44.7 N.A. 58.9 69.7
P-Site Identity: 100 100 100 53.3 N.A. 100 100 N.A. 86.6 86.6 73.3 73.3 N.A. 6.6 N.A. 40 66.6
P-Site Similarity: 100 100 100 80 N.A. 100 100 N.A. 86.6 93.3 86.6 86.6 N.A. 20 N.A. 80 86.6
Percent
Protein Identity: N.A. 29.3 N.A. 40 25.6 N.A.
Protein Similarity: N.A. 44.4 N.A. 53.5 41.2 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. 20 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 7 0 0 0 0 13 0 0 13 7 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 13 0 7 7 75 0 7 0 19 7 13 7 0 0 % D
% Glu: 0 0 0 7 7 0 7 0 7 0 7 0 7 0 7 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 75 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 7 7 0 7 0 0 0 0 % I
% Lys: 7 0 0 0 7 13 13 0 7 0 0 0 0 7 19 % K
% Leu: 0 0 75 69 0 0 0 0 0 0 7 0 0 0 0 % L
% Met: 0 0 7 7 0 0 57 0 0 0 0 0 0 0 7 % M
% Asn: 0 57 0 0 57 0 0 0 0 0 0 69 0 0 0 % N
% Pro: 7 0 7 0 7 7 0 7 75 69 7 7 75 50 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 44 % R
% Ser: 0 25 0 0 13 0 0 19 0 0 0 0 0 32 7 % S
% Thr: 0 0 0 0 0 0 0 50 0 0 0 13 0 7 0 % T
% Val: 0 0 0 7 0 0 19 7 0 0 63 0 0 0 7 % V
% Trp: 0 0 7 0 0 0 0 0 7 0 7 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _